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Furthermore, premalignant lung lesions have a high regression rate, with 66% of lesions spontaneously resolving (59), suggesting that a large proportion of patients with premalignant lesions may never be identified in the population, particularly in populations with a high proportion of current and former smokers, despite the theoretical potential for these lesions to produce detectable amounts of CR

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Although some references reported a certain degree of association with SHS, the review concluded that the available evidence on the etiology of this neoplasm in cats is still limited 39

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To some of the most earnest missionary clergy, the wreaths of its smoke and its action upon the spirits of those who imbibed it were a kind of sacramental parody of the Churchs sacraments, established in the New World beforehand by the Devil in order to hinder its evangelization